A variety of biological activities have been ascribed to betulinic acid including anti-inflammatory and in vitro antimalarial effects however, betulinic acid is most highly regarded for its anti-hiv-1 activity and specific cytotoxicity against a variety of tumor cell lines. Triterpenes like betulin, lupeol and especially betulinic acid, the main components of birch bark with lupan skeleton (figure 1) display anticancer and other important therapeutic activities [1. Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (hiv), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties.
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of betula alba, the common white birch) with antiinflammatory, anti-hiv and antineoplastic activities. Due to the high mutagenecity of hiv-1 and cancers cells in order to improve the biological activity of betulin and its derivatives various strategies were applied and still going on (csuk, 2014), here we are presenting a coverage of the betulin, betulinic acid and its derivatives with their biological activity.
Recent studies on betulinic acid and its biological and pharmacological activities acknowledgements this study was supported by the regional innovation center for dental science & engineering, chosun university, gwangju, korea (b0008940. Betulin 1 can be easily converted to relatively non-toxic betulinic acid 2, which has shown to possess wide spectrum of biological activities betulinic acid 2 and its derivatives have been shown to possess antimalarial, anti-inflammatory and antifungal activity. Mg/g betulin of bark while acid betulinic had average values of 1060 ± 097 mg/g bark statistically, significant differences were noticed between the two regions, the first region being richer in these molecules. Betulin is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents it has a role as a metabolite, an antiviral agent, an analgesic, an anti-inflammatory agent and an antineoplastic agent.
It can be converted to betulinic acid (the alcohol group replaced by a carboxylic acid group), which is biologically more active than betulin itself betulin contains betulinic acid, which possesses a wide spectrum of biological and pharmacological activities. Betulinic acid exerts a number of biological activities for example, betulinic acid has been shown to have antitumor properties to this end, it is interesting to note that white birch bark (betula alba) which contains betulinic acid, has been used by native americans as a folk remedy. The original extract, fraction without betulinic acid and lupeol, amorphous fraction of pure betulin, final crystalline fraction of pure betulin and commercial betulin as a standard were employed to determine the antiproliferative/cytotoxic effect. Recent studies on betulinic acid and its biological studies performed to evaluate the biological and pharmacological activities of ba and its de- sleet ce betulin-betulinic acid natural.
120 biological activity of betulinic acid: a review figure 1 structures of betulinic acid and betulin 3 anti-hiv activity betulinic acid was isolated from the meoh extract of the. By oxidation of the c-28 hydroxylic group to carboxyl, betulin can be rapidly converted to its more active derivate, betulinic acid, with a wide spectrum of biological and pharmacological activities such as: anti-inflammatory, antimalarial, anti-hiv, antineoplasic [8, 9. Betulinic acid crystals have been obtained and there were characterized by the evaluation of their aspect, size and stability and by in vivo assays using the animal model of skin parameters.
Literature dealing with betulinic acid related biological properties that has appeared from the 1990's to the beginning of 2003 a broad range of medical and pharmaceutical disciplines are covered, including a brief. Abstract betulinic acid is a known natural product which has gained a lot of attention in the recent years since it exhibits a variety of biological and medicinal properties.
Betulinic acid is a known natural product which has gained a lot of attention in the recent years since it exhibits a variety of biological and medicinal properties this review provides the most important biological properties of betulinic acid. Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.